The Effect of Vitamin C on Tooth Growth in Guinea Pigs

The response is the length of odontoblasts (cells responsible for tooth growth) in 60 guinea pigs. Each animal received one of three dose levels of vitamin C (0.5, 1, and 2 mg/day) by one of two delivery methods, (orange juice or ascorbic acid (a form of vitamin C and coded as VC).




A data frame with 60 observations on 3 variables.

[,1] len numeric Tooth length
[,2] supp factor Supplement type (VC or OJ).
[,3] dose numeric Dose in milligrams/day


C. I. Bliss (1952) The Statistics of Bioassay. Academic Press.


McNeil, D. R. (1977) Interactive Data Analysis. New York: Wiley.

Crampton, E. W. (1947) The growth of the odontoblast of the incisor teeth as a criterion of vitamin C intake of the guinea pig. The Journal of Nutrition 33(5): 491–504.


coplot(len ~ dose | supp, data = ToothGrowth, panel = panel.smooth,
       xlab = "ToothGrowth data: length vs dose, given type of supplement")
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Attachment Size
dataset-81319.csv 760 bytes