On this R-data statistics page, you will find information about the colon data set which pertains to Chemotherapy for Stage B/C colon cancer. The colon data set is found in the survival R package. You can load the colon data set in R by issuing the following command at the console data("colon"). This will load the data into a variable called colon. If R says the colon data set is not found, you can try installing the package by issuing this command install.packages("survival") and then attempt to reload the data. If you need to download R, you can go to the R project website. You can download a CSV (comma separated values) version of the colon R data set. The size of this file is about 79,828 bytes.
Chemotherapy for Stage B/C colon cancer
These are data from one of the first successful trials of adjuvant chemotherapy for colon cancer. Levamisole is a low-toxicity compound previously used to treat worm infestations in animals; 5-FU is a moderately toxic (as these things go) chemotherapy agent. There are two records per person, one for recurrence and one for death
R project statistics dataset table
||1 for all patients
||Treatment - Obs(ervation), Lev(amisole), Lev(amisole)+5-FU
||obstruction of colon by tumour
||perforation of colon
||adherence to nearby organs
||number of lymph nodes with detectable cancer
||days until event or censoring
||differentiation of tumour (1=well, 2=moderate, 3=poor)
||Extent of local spread (1=submucosa, 2=muscle, 3=serosa, 4=contiguous structures)
||time from surgery to registration (0=short, 1=long)
||more than 4 positive lymph nodes
||event type: 1=recurrence,2=death
The study is originally described in Laurie (1989). The main report is found in Moertel (1990). This data set is closest to that of the final report in Moertel (1991). A version of the data with less follow-up time was used in the paper by Lin (1994).
JA Laurie, CG Moertel, TR Fleming, HS Wieand, JE Leigh, J Rubin, GW McCormack, JB Gerstner, JE Krook and J Malliard. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil: The North Central Cancer Treatment Group and the Mayo Clinic. J Clinical Oncology, 7:1447-1456, 1989.
DY Lin. Cox regression analysis of multivariate failure time data: the marginal approach. Statistics in Medicine, 13:2233-2247, 1994.
CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, PJ Goodman, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. New England J of Medicine, 332:352-358, 1990.
CG Moertel, TR Fleming, JS MacDonald, DG Haller, JA Laurie, CM Tangen, JS Ungerleider, WA Emerson, DC Tormey, JH Glick, MH Veeder and JA Maillard, Fluorouracil plus Levamisole as an effective adjuvant therapy after resection of stage II colon carcinoma: a final report. Annals of Internal Med, 122:321-326, 1991.
Dataset imported from https://www.r-project.org.