This dataset was taken from the list of OpenIntro dataset files found at https://www.openintro.org/data/.
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Malaria Vaccine Trial
Volunteer patients were randomized into one of two experiment groups where they would receive an experimental vaccine or a placebo. They were subsequently exposed to a drug-sensitive strain of malaria and observed to see whether they came down with an infection.
- treatment - Whether a person was given the experimental vaccine or a placebo.
- outcome - Whether the person got an infection or no infection.
In this study, volunteer patients were randomized into one of two experiment groups: 14 patients received an experimental vaccine or 6 patients received a placebo vaccine. Nineteen weeks later, all 20 patients were exposed to a drug-sensitive malaria virus strain; the motivation of using a drug-sensitive strain of virus here is for ethical considerations, allowing any infections to be treated effectively.
Lyke et al. 2017. PfSPZ vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. PNAS 114(10):2711-2716. http://www.pnas.org/content/114/10/2711
Taken from: https://www.openintro.org/data/index.php?data=malaria.